Human Saliva Acting as an Allergen

Dog saliva – an important source of dog allergens

BACKGROUND Allergy to dog (Canis familiaris) is a worldwide common cause of asthma and allergic rhinitis. However, dander extract in routine diagnostics is not an optimal predictor of IgE-mediated dog allergy. Our objective was to evaluate saliva as an allergen source for improved diagnostics of allergy to dog. METHODS IgE-binding proteins in dog saliva and dander extract were analysed by imm...

Molecular allergology

Background Allergy diagnosis is based on the history, clinical symptoms and physical examination of the patient in combination with results of in vivo and in vitro test. Today the allergy diagnosis can be refined using molecular allergology, which allows the quantification of allergen specific IgE antibodies to a single, pure allergen molecule (component). This contributes to a more exact diagn...

Secretion of Food Allergen Proteins in Saliva

Anaphylaxis as a Manifestation of Horse Allergy

Allergic disease induced by animal exposure is a common phenomenon worldwide. Whereas cat and dog dander exposure are well recognized as causative of allergic rhinitis, allergic asthma, and contact urticaria, horse allergy can present with anaphylaxis. Horse allergy is induced by exposure to the major horse allergens Equ 1 through 5. The severity of the symptoms may be related to the level of e...

Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.

Greater clinical benefit in controlling the symptoms of asthma is frequently observed through combining moderate doses of inhaled glucocorticoids together with long-acting beta(2)-agonists, as compared with increasing glucocorticoid dosage alone. To address in vitro whether glucocorticoids plus beta(2)-agonists, compared with glucocorticoids alone, have greater inhibitory activity on CD4+ T cel...